Targeting ‘simple proteins’ may extend metabolic healthspan

FABP’s are fatty-acid binding proteins, which are found in abundance in heart and liver tissue. A new study suggests keeping FABP levels very low may extend teh metabolic healthspan.

In the study, conducted at the T. H. Chan School of Health at Harvard University, researchers altered levels of these proteins in mice.

The research team was led by Gokhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases. The findings were published in the journal “Cell Reports”.

Key Takeaways:

  • Fatty acid binding protein (FABP) move fat molecules in cells. FABP occur in high numbers in the heart and liver. Keeping FABP low may assist in healthy metabolism.
  • Research shows that high calorie diets slow metabolism while low calorie diets inhibit the aging process and metabolic-related illness.
  • FABP is being researched and early findings suggest low levels of FABP lead to decreased risk of cardiovascular disease and lower cholesterol. These two effects can lead to healthier aging.

“From a public health perspective, extending the number of years that people are healthy would be a huge achievement. Our findings show that this may be possible through a mechanism that can be translated into human populations through pharmacological and nutritional interventions.”

Read more:

Open menu